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Acrodermatitis enteropathica (AE) is caused by SLC39A4 mutations leading to severe zinc deficiency and manifest clinically by acral dermatitis, alopecia, diarrhea and growth failure. AE usually presents in the first months of life in infants that are not breast-fed and at the time of weaning in breast-fed infants, as cow’s milk contains more zinc-binding phytates that impede zinc absorption. In...
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ژورنال
عنوان ژورنال: Nature
سال: 2003
ISSN: 0028-0836
DOI: 10.1038/nj6927-095a